In March 2020, we initiated the network covid19-nmr and set out the following milestones:
- Make as many viral RNA and proteins as possible available for NMR work and screen them by a fragment library.
- Share data and make data available prior to publication (covid19-nmr.de).
In September 2022, we have achieved these milestones and published the following paper.
Viral RNA availability for NMR
Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy Nucleic Acids Res. 2020 Dec 16;48(22):12415-12435. doi: 10.1093/nar/gkaa1013
Viral protein availability for NMR
Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications
Front Mol Biosci. 2021 May 10;8:653148. doi: 10.3389/fmolb.2021.653148. eCollection 2021
Viral RNA Screening
Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS-CoV-2 Genome
Angew Chem Int Ed Engl. 2021 Aug 23;60(35):19191-19200. doi: 10.1002/anie.202103693
Viral protein Screening
Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug Development
Angew Chem Int Ed Engl. 2022 Sep 17:e202205858. doi: 10.1002/anie.202205858
We wish to thank everyone who contributed to our joint efforts.
After consultation with the governance board and discussion in the last Covid19-NMR zoom meeting, we think we should now transform our network towards a discussion group on “Virus research by NMR and beyond”.
We will meet online every two months and invite you to contact Harald (schwalbe@nmr.uni-frankfurt.de), if you wish to present some new exciting work. We also have the aim to connect to other communities, so please share this with others interested in the field.