COVID19-NMR

A new paper from Covid19-NMR participants was recently published in “Science Advances“. RNA-targeted antivirals have been identified using cytotoxicity and SARS-CoV-2 antiviral assays, NMR profiling, virtual ligand screening and small-molecule docking. Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures The current pandemic and likelihood of future coronavirus pandemics, emphasized the urgent need for […]

Our Screening paper “Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome” published in Angewandte Chemie already received quite some attention in several media. Additionally, a recent published article in the national newspaper Süddeutsche Zeitung highlights the outcome of different research groups involved in drug discovery against SARS-CoV-2, including the International Covid19-NMR […]

Our Screening paper “Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome” is now online in Angewandte Chemie. A poised fragment library of 768 compounds was screened for the binding ability to 15 RNA elements of SARS-CoV-2. 69 fragments bound to 13 of 15 RNA elements and three fragments highly specific. Those […]