Prof. Dr. Samuel E. Butcher
My laboratory utilizes biochemical and biophysical approaches to gain insight into RNA and RNP structure and dynamics. We gain important insights into RNP structure and function by testing our hypothesis in vitro and in living cells. My laboratory has determined over 40 high-resolution structures of RNAs and RNPs that are essential for gene expression. We have helped to pioneer the use of hybrid NMR-SAXS methods for RNA structure determination and the use of dynamic measurements combined with simulations to describe conformational transitions in RNA. I have been a member of the leadership team for the National Magnetic Resonance Facility at Madison (NMRFAM) for 20 years and have assisted and collaborated with many users of this facility.