Prof. Dr. Kurt Wüthrich

Scripps Research Institute, La Jolla, CA, USA

For 50 years, Wüthrich groups at the ETH Zürich, Zürich, Switzerland, at Scripps Research, La Jolla, CA, USA and at the iHuman Institute of ShanghaiTech University, Shanghai, China have worked on nuclear magnetic resonance spectroscopy (NMR) with biological macromolecules. Contributions include the method for macromolecular structure determination with NMR in solution and the use of the principles of transverse relaxation-optimized spectroscopy (TROSY) for NMR experiments with large supramolecular assemblies. Applications over the years were focused on differentiation in higher organisms, immune suppression and neuropathology.  As of April 2019, research using NMR techniques is continued at ShanghaiTech University, with a focus on trans-membrane signal transfer by G protein-coupled receptors (GPCRs). At Scripps Research and the ETH Zürich, projects on the general theme “healthcare in the ageing human societies of the 21st century” are pursued, mainly considering the impact of sarcopenia on the human healthspan.