Prof. Dr. Blanton S. Tolbert

Case Western Reserve U., Cleveland, OH, USA

My lab endeavors to understand the mechanisms by which RNA viruses usurp cellular machinery to sustain chronic and lifelong infections. To accomplish this, we integrate multiple biophysical and biochemical approaches to obtain different views of RNA elements and complexes. I have 10+ years of experience in determining high-resolution NMR structures of RNAs from HIV and EV71, viral pathogens that continue to cause serious health complications. My lab has also determined structural models of RNP complexes that inform on mechanisms by which these viruses usurp host machinery. Further, we collaborate with leading virologists to interpret our results in a biological context.