Prof. Dr. Achilleas Frangakis
The main focus is to reveal the macromolecular organization of living cells by means of cryo-electron tomography. Cryo-electron tomography is the only technique that allows to obtain molecular resolution images of intact cells in a quasi-native environment. The tomograms contain an imposing amount of information; they are essentially a three-dimensional map of the cellular proteome and depict the whole network of macromolecular interactions. Information mining algorithms exploit structural data from various techniques, identify distinct macromolecules and computationally fit atomic resolution structures in the cellular tomograms, thereby bridging the resolution gap.