Dr. Philip Gribbon

Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Hamburg

The Fraunhofer team have access to a panel of biochemical assays against Sars-CoV-2 viral targets (including nsp5 and nsp3 with others under development) which can be accessed for profiling of NMR identified hits. These assay tools were developed in the framework of the Exscalate4Cov EU project and have been validated in parallel studies on large scale repurposing libraries. In addition, we bring in expertise in Medicinal Chemistry (Andrea Zaliani) for elaboration of fragment hits and determination of compound mechanism of action.