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COVID19-NMR

COVID19-NMR

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Publications

DOI

Biomol NMR Assign (2021). Published online.

1H, 13C and 15N assignment of stem-loop SL1 from the 5′-UTR of SARS-CoV-2

C. Richter, K. F. Hohmann, S. Toews, D. Mathieu, N. Altincekic, J. Kaur Bains, O. Binas, B. Ceylan, E. Duchardt‑Ferner, J. Ferner, B. Fürtig, J. T. Grün, M. Hengesbach, D. Hymon, H. R. A. Jonker, B. Knezic, S. M. Korn, T. Landgraf, F. Löhr, S. A. Peter, D. J. Pyper, N. S. Qureshi, A. Schlundt, R. Schnieders, E. Stirnal, A. Sudakov, J. Vögele, J. E. Weigand, J. Wirmer‑Bartoschek, K. Witt, J. Wöhnert, H. Schwalbe, A. Wacker

The stem-loop (SL1) is the 5′-terminal structural element within the single-stranded SARS-CoV-2 RNA genome. It is formed by nucleotides 7–33 and consists of two short helical segments interrupted by an asymmetric internal loop. This architecture is conserved among Betacoronaviruses. SL1 is present in genomic SARS-CoV-2 RNA as well as in all subgenomic mRNA species produced by the virus during replication, thus representing a ubiquitous cis-regulatory RNA with potential functions at all stages of the viral life cycle. We present here the 1H, 13C and 15N chemical shift assignment of the 29 nucleotides-RNA construct 5_SL1, which denotes the native 27mer SL1 stabilized by an additional terminal G-C base-pair.

Funded by


Goethe Corona Fonds

DFG

Volkswagen Stiftung

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Coordination

Prof. Dr. Harald Schwalbe (Coordinator)
Institut für Organische Chemie und Chemische Biologie
Zentrum für Biomolekulare Magnetische Resonanz

Johann Wolfgang Goethe-Universität
N160-3.13
Max-von-Laue-Strasse 7
D-60438 Frankfurt am Main

Contact us

++49 69 798 29737
schwalbe@nmr.uni-frankfurt.de

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